You probably have to procmon it to see what the problem is.
And then post to either the Microsoft TechNet or AppVirtGuru forums to get help with more detail of the issue. I am not trying to make this site a general forum for App-V issues, and you'll find lots of people that can help this kind of issue on those sites.
I created a middleware AppV package of Java 6u45 (x86)
Using RES Workspace Manager I start IE11 with /appvve and start IE with the 6u45 plugin...that works correctly
But when starting the default IE11 (within /appvve option) also shows the plugin enabled nd when starting I get a prompt that it tries to do something at the AppV package location to which it does not have access....
Any idea what I do wrong here ?